Photodynamic therapy for the enhancement of vascular permeability to aid in drug delivery to diseased tissues

摘要

A method for treating aberrant tissue in an animal that includes the following steps. A photosensitive agent is introduced into the blood stream of an animal that has better selectivity for the aberrant tissue than normal tissue to obtain aberrant tissue containing the photosensitizing agent. The aberrant tissue containing the photosensitizing agent is exposed to light to activate the photosensitizing agent to increase permeability of vasculature in the aberrant tissue; and a treating agent is introduced into the bloodstream of the animal, which treating agent passes through the vasculature having increased permeability into the aberrant tissue to treat the aberrant tissue.