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Accesory cholera enterotoxin and analogs thereof as activators of calcium dependent chloride channel
Accesory cholera enterotoxin and analogs thereof as activators of calcium dependent chloride channel
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机译:辅助霍乱肠毒素及其类似物作为钙依赖性氯通道的激活剂
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摘要
Vibrio cholerae accessory cholera enterotoxin (ACE) activates a calcium dependent chloride channel. Ace and Ace analogs can be administered to patients to treat diseases involving defects in chloride secretion by the cystitis fibrosis transmembrane receptor (CFTR). Cystic fibrosis, Dent's disease, X-linked nephrolithiasis, X-linked recessive hypophosphatemic rickets, autosomal dominant myotonia congenita and autosomal recessive general myotonia can be treated by the administration of Ace or an Ace analog. For cystic fibrosis, administration of Ace or an Ace analog increases chloride secretion in the lungs which increases the amount of airway surface water in the lumen of the lungs.
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