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Inhibiting retrotransposon and retroviral integration by targeting the atm pathway
Inhibiting retrotransposon and retroviral integration by targeting the atm pathway
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机译:通过靶向atm途径抑制逆转录转座子和逆转录病毒整合
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摘要
Ataxia telangiectasia mutated (ATM)-dependent DNA damage signalling mechanisms are involved in retroviral and retrotransposon integration. Screening methods for inhibitors of retroviral and retrotranspons activity comprise inhibiting the ATM-dependent DNA damage signalling pathway, e.g. by disrupting interaction between components of the pathway. Inhibitors are useful as anti-retroviral agents, e.g. in inhibition of HIV.
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