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Inotropic effects of antibodies on cardiac contraction
Inotropic effects of antibodies on cardiac contraction
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机译:抗体对心脏收缩的正性肌力作用
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摘要
The present invention shows that site-specific antibodies to the (Na++K+)-ATPase exert a potent biological effect in cardiac myocytes and demonstrates a key structural region of the enzyme that participates in the regulation of cardiac contractility. These results establish an important link between a biological action and a precise molecular structure of the (Na++K+)-ATPase. Furthermore, the antibody-induced positive inotropic effect is independent of inactivation of the enzyme may reveal a novel mode for (Na++K+)-ATPase to regulate cardiac function. The data provide new molecular insights into the structural and functional relationship of the ubiquitous (Na++K+)-ATPase.
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机译:本发明显示了针对(Na + Sup>+ K + Sup>)-ATPase的位点特异性抗体在心肌细胞中发挥了强大的生物学作用,并显示出关键的结构参与心脏收缩力调节的酶区域。这些结果建立了(Na + Sup>&K; K + Sup>)-ATPase的精确的分子结构与生物学作用之间的重要联系。此外,抗体诱导的正性肌力作用与酶的失活无关,可能揭示了(Na +; Sup>&K; K + Sup>)-ATPase调节的新模式。心功能。这些数据为普遍存在的(Na + Sup>+ K + Sup>)-ATPase的结构和功能关系提供了新的分子见解。
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