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Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen
Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen
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机译:使用异种CD20抗原刺激对CD20的免疫应答的方法和组合物
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摘要
Tolerance of the immune system for endogenous CD20 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed CD20 antigen. For example, mouse CD20, or antigenically-effective portions thereof, can be used to stimulate an immune response to the corresponding differentiation antigen in a human subject. Administration of xenogeneic antigens in accordance with the invention results in an effective immunity against CD20 expressed by the cancer in the treated individual, thus providing a therapeutic approach to the treatment of lymphomas and leukemia expressing CD20.
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