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Proteome analysis method and proteome analysis system
Proteome analysis method and proteome analysis system
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机译:蛋白质组分析方法和蛋白质组分析系统
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摘要
A proteome analysis method and a proteome analysis system, which identifies proteins by using a mass spectrometer, in particular, which has the high accuracy and the high throughput, by using predicted results of bond cleavage parts by a molecular simulation method such as an MO method, are provided. Further, at the method and the system, even when the number of samples for identification is small, the number of times of its experiment can be decreased, and peak values buried under noise in a mass spectrum are added. And at the system, even when a new protein, which has not been registered in a protein sequence database, can be identified. For achieving this, at the proteome analysis method by using a tandem type mass spectrometer, bond dissociation energy is calculated by using a molecular simulation method, and prediction information of a cleavage pattern of a peptide and/or peak positions in a mass spectrum and/or the intensity ratio of said mass spectrum are obtained, and the prediction information is added to experiment information, and the added information is used for identification of a protein.
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