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Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins
Methods of therapy and diagnosis using targeting of cells that express toll-like receptor proteins
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机译:使用靶向表达Toll样受体蛋白的细胞进行治疗和诊断的方法
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摘要
Certain cells, including types of cancer cells such as B-cell lymphomas, T cell lymphomas, Hodgkins disease and myeloid leukemias, are capable of expressing Toll-like Receptor 9 (TLR9) or Toll-like Receptor 10 (TLR10) mRNA. Immunotargeting using TLR9 or TLR10 polypeptides, nucleic acids encoding for TLR9 or TLR10 polypeptides and anti-TLR9 or anti-TLR10 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the TLR9 or TLR10 protein. Methods of immunotherapy and diagnosis of disorders associated with TLR9 or TLR10 protein-expressing cells, such as B-cell lymphoma, T cell lymphoma, acute myeloid leukemia, Hodgkins disease, B cell leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia and myelodysplastic syndromes, are described.
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