Methods for chronic disease diagnosis based on microcompetition with a foreign polynucleotide

摘要

Microcompetition between a foreign polynucleotide and a cellular polynucleotide is a risk factor associated with chronic disease. The invention uses this novel discovery to present assays for the diagnosis of chronic disease. The assays are based on measuring the cellular copy number of the foreign polynucleotide, measuring the rate of complex formation between the microcompeted cellular transcription factor and either the foreign polynucleotide or the cellular polynucleotide, identifying modified expression of a gene susceptible to microcompetition with a foreign polynucleotide, or identifying modified activity of a gene product of a gene susceptible to microcompetition with a foreign polynucleotide. The invention also presents other foreign polynucleotide-type assays