Compositions and methods relating to ABCA1-mediated cholesterol efflux

摘要

This invention provides a method for determining whether an agent increases ABCA1-dependent cholesterol efflux from a cell. This invention also provides methods for increasing cholesterol efflux from a cell and for decreasing the amount of cholesterol in a cell. This invention further provides methods for increasing the likelihood that a cholesterol-loaded macrophage will survive and for decreasing the likelihood that a cholesterol-loaded macrophage will contribute to the progression of atherosclerosis. Finally, this invention provides a method for treating a subject afflicted with atherosclerosis, and a related article of manufacture.