首页> 外国专利> Pyrimidine linked pyrroloamp;lsqb;2,1-camp;rsqb;amp;lsqb;1,4amp;rsqb;benzodiazepines as potential antitumour agents

Pyrimidine linked pyrroloamp;lsqb;2,1-camp;rsqb;amp;lsqb;1,4amp;rsqb;benzodiazepines as potential antitumour agents

机译:嘧啶连接的吡咯并2,1-c][ 1,4]苯二氮卓类药物可能是抗肿瘤药

摘要

The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepines useful as potential antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepines as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[6′-(4″-fluorophenyl)-2′-methylpyrimidine-4′-yloxy]alkoxy-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1,c][1,4]benzodiazepin-5-one with aliphatic chain length variations for the compounds and it also describes the anticancer (antitumour) activity. The structural formula of novel pyrrolo[2,1-c][1,4]benzodiazepine is as follows. embedded image
机译:本发明涉及一种制备新颖的吡咯并2,1-c和1,1,4和苯并二氮杂用作潜在抗肿瘤剂的方法。本发明还涉及制备作为潜在抗肿瘤剂的新型吡咯并2,1-c&rsqb; 1,4&rsqb;苯并二氮杂process的方法。更特别地,它提供了一种制备7-甲氧基-8-Isqb; 6-prime ;-( 4-Prime;-氟苯基)-2&prime;-甲基嘧啶-4&prime; -yloxy&rsqb;烷氧基-(11aS)-1,2,3的方法。化合物的脂族链长变化的1,11a-四氢-5H-吡咯并1、2,1,c&rsqb;&lsqb; 1,4&rsqb;苯并二氮杂-5--1-酮,并且还描述了抗癌(抗肿瘤)活性。新型吡咯并2,1-c-rs 1,4-苯二氮杂的结构式如下。 <图像alt =“嵌入式图像” file =“ US06683073-20040127-C00001.GIF” he =“ 90.4932” id =“ EMI-C00001” imgContent =“ undefined” imgFormat = “ GIF” wi =“ 210.7539” />

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