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Methods for carbon-centered radical mediated heavy hydrogen labeling of compounds
Methods for carbon-centered radical mediated heavy hydrogen labeling of compounds
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机译:以碳为中心的自由基介导的化合物重氢标记的方法
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摘要
The solvent accessible reduced carbon atoms in a molecule of interest are labeled with heavy hydrogen. The carbon atoms are labeled under anaerobic, aqueous conditions by exposing the molecule of interest to a hydrogen atom abstractor in the presence of a heavy hydrogen source and a heavy hydrogen donor. If the hydrogen atom abstractor is hydroxyl radical, an electron scavenger source is provided. Optionally, an internal reference is provided to facilitate experimental reproducibility.
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