A procedure to produce the Crystalline Form I of cabergoline, i.e., 1 ((6 - alilergolin - 8beta - yl) - carbonyl) - 1 - (3-dimethylaminopropyl) - 3-ethylurea, solvate form V of cabergoline, and a procedure to produce the solvate form V of cabergoline

摘要

A procedure to produce the Crystalline Form I of cabergoline, i.e., 1 ((6 - alilergolin - 8beta - yl) - carbonyl) - 1 - (3-dimethylaminopropyl) - 3-ethylurea, procedure that involves the crystallization of the desired shape from a mixture of toluene / diethyl ether comprising cabergoline cru Da, followed by recovery and drying the resulting crystals.It also provides a new form of cabergoline V solvate, useful as an intermediate, and a procedure to produce the solvate form V of cabergoline.The Way I like Dostinex, cabergoline, presents a significant inhibitory effect on prolactin and has Therapeutic properties that make it possible to treat patients with Pathological conditions associated with an abnormal level of prolactin, therefore is useful in Human and / or Veterinary Medicine.The form I of cabergoline is particularly useful in the treatment of Parkinson's Disease (PD), Restless legs syndrome (RLS), the treatment of diseases such as Progressive Supranuclear Palsy (PSP) and multiple system atrophy (MSA).