Process for preparing Pharmaceutical compositions in rapidly DISINTEGRATING TABLETS substantially free of Crystals of the pharmacologically Active principle from the modification of the Crystalline structure of the agent during the operations of Manufacturing the same

摘要

Pharmaceutical compositions for oral and sublingual tablets, distinguishable by their small size and rate of Decay increased with respect to conventional tablets. These characteristics diferenciantes, from the preliminary Procedure of the active Agent in solution with the Binder component.Since the excipients and loads and a fraction of the Lubricating Component to form a First and a Second granulated Granules from the first pre ground and mixed with the remaining fraction of lubricant and final conformation of the resulting mixture, in sustancialme tablets Nte free Crystals of the active Agent.Pharmaceutical compositions in tablets obtained with this procedure.