A transdermal Therapeutic System comprising microreservorios and a procedure for Manufacturing Systems based on ambifilos microreservorios Polysiloxanes and solvents.

摘要

The external skin disease treatment system includes an impermeable back layer of the active substance, at least a polymer layer containing a micro reservoir, at least one active substance and a protective layer removed before use, before use: the polymer contained in the polymer layer is polyamide. At least 70% by weight and preferably at least 80% by weight of the active substance contained in the micro set: at least 50% in the solvent of the active substance,Better be at least 80%2. In terms of weight, ambifilo organic solvent, especially dipolar: ambifilo solvent, shall not be more than 20% dissolved in polysiloxane by weight, preferably mixed with water in the weight ratio of at least 1 solvent (3 water); A procedure for the production of a micro reservoir system containing an active substance in which the active substance dissolves into an ambifilo solvent, in which at least 50% by weight contains a diode organic solvent, which is dispersed in a polyacyl hydroxy solution, and the resulting dispersion is suitable for Lining pattern on appropriate furnaceand the polysiloxane solvent is removed at temperatures between 25 and 100 ° C, preferably between 30 and 80 ° C.