Compounds 4 - (1R) - 4 - piperidilen) - 4H - benzo 4,5 cyclohepta 1,2 thiophene - 1 - and its optically Active isomers, a method for their Synthesis and use of such compounds for the manufacture of a medicament

摘要

A compound 4 - (1r-4-piperidilen) - 4H benzo [4.5] cycloheppa [1.2] - tiofeno-1-a, including (1) structure (1), wherein a is - co-o-chph - and R is CH3 or h, and a three-dimensional form formed with chemical plasma and troposphere, provided that if R is CH3, a is not co; if R is h, R is not Co. If the compound is an racemate, R is CH3; if the compound is an racemate, R is h, C is racemato; if the compound is an racemate, R is CH3, R is CH3. Norketotimeno racticiden, 10-hydroxi-ketotimeno racticiden were found,The 10-hydroxy-norkatotiphen external disinfectant, as well as the optical active isomers of ketamine, norketotiphen, 10-hydroxy-ketamine and 10-hydroxy-norkatotiphen, have anti allergic and anti-inflammatory effects, but lack of ketamine dose has serious side effects. In addition, the methods of synthesizing these compounds and using them in the manufacture of drugs for the prevention or treatment of diseases selected from groups such as respiratory disorders, allergic disorders, skin disorders, gastrointestinal disorders and eye diseases are also introduced.