A process for preparing compounds tetrazin imidazo - 4 - One Compounds, Intermediates, addition salts of acids, a process to prepare temozolomide, a process for preparing Intermediates

摘要

A process for the preparation of a compound tetrazin imidazo - 4 - one of the formula (1) wherein R is an alkyl group C1 - 6, diazotar comprises (a) a compound of the formula (2) in which R is as defined above; and pg 'is a divalent Group protector can be easy Separated easily by hydrolysis or hydrogenolysis.Pg monovalent or two Protective groups that can be easily separated by hydrolysis and hydrogenolysis, or a monovalent bulky Protecting Group pg that can be easily separated by hydrolysis and hydrogenolysis, together with a hydrogen Atom; and then (b) subjecting the compue Sto thus obtained, the formula (3); Intermediate Compounds, acid Addition salts,A process for preparing temozolomide, a process for preparing Intermediates, Synthesis of temozolomide, an antitumor Compound, and its analogues and Intermediates useful in this process.