1.3 - diaminopropane substituted Derivatives, Process for their preparation, medicinal and Pharmaceutical compositions containing them and Use thereof for the preparation of medicaments for the prophylaxis and / or treatment of urinary incontinence, Pain, pruritus, tinnitus, diarrhea and / or AURIUM

摘要

1. The derivatives of propane-1,3-diamond were replaced by No.1 total structure;R1 represents C1-12, cycloquilo C3-8, (c1-6-tar) - cycloquilo C3-8 or arilo; R2 represents C1-12, cycloquilo C3-8, arilo, (c1-6-tar) - cyclo-8, (C1-6) - arilo, isopropene, isopropyl or - (c1-6-tar) - isopropene, provided that R1 and 2 are both asymmetric or asymmetric. R2 together forms the radical - (CH2) m -.6) - C1-6) - c1c1-6 - (c1c1-6) - C1-6) - R7; R4 represents h, C1-12, C1-12, cycloquilo C3-8, arilo, - (c1-6-tar) - cycloquilo C3-8, - (c1-6-tar) - arilo, isopropene or - (c1-6-tar) - isopropene; or R3 and R4 combine to form radical - (CH2) n -,N = 3, 4, 5, 6 or 7, or radical - (CH2) 2-x - (CH2) 2,where X = O, S or NR8, and in which - (CH2) n- or - (CH2) 2-X- (CH2) 2- can be unsubstituted or substituted with C1-6 alkyl, R5 and R6 independently represent between yes C1-12 alkyl, C3-8 cycloalkyl, aryl, - (C1-6 alkyl) -C3-8 cycloalkyl, (C1-6 alkyl) -aryl, or together form the radical - (CH2) or-,If o = 3, 4, 5, 6 or 7, or radical - (CH2) 2 - (CH2) 2,where Y = O, S or NR9, being able to - (CH2) or- or - (CH2) 2-Y- (CH2) 2 be unsubstituted or substituted with C1-6 alkyl; A represents aryl, heteroaryl, C (= O) OR10 or 2-propyl; R 7 represents C 1-6 alkyl, C 3-8 cycloalkyl, aryl, heterocyclyl, - (C 1-6 alkyl) -C 3-8 cycloalkyl, - (C 1-6 alkyl) -aryl or - (C 1-6 alkyl) -heterocyclyl; R 8 and R 9 independently represent each other H, C 1-6 alkyl, C 3-8 cycloalkyl, aryl, - (C 1-6 alkyl) -C 3-8 cycloalkyl, - (C 1-6 alkyl) -aryl, or heterocyclyl; R 10 represents C 1-6 alkyl, C 3-8 cycloalkyl, aryl, - (C 1-6 alkyl) -C 3-8 cycloalkyl, or - (C 1-6 alkyl) -aryl; the compound of the general structure (1) being in the form of a racemate,1. In the form of one or more non enantiomers or one or more corresponding isomers, but compounds n, N-dimethyl - [phenyl - (2-pirrolidin-1-il-cyclohexyl) - methyl] - amines, N, N-dimethyl - [(2-moroflin-4-il-cyclohexyl) - phenyl methyl] - amines, 4 - [phenyl - (2-pirrolidin-1-il-cyclohexyl) - methyl] - pyrylides - methyl methyl methyl methyl methyl methyl methyl Di Di Di Di Di 1,3-diphenyl-3 - (n; n-diethylmethyl) - propyl) - amine, 4 - (1, 3-diphenyl-3-pirolin-1-il-propylmorphine,N. N, N-dimethyl - (2-methyl-1-phenyl-3 - (morfolin-4-il) - pentachlorobenzene) - amine, benzene - [2 - (dimethyl-phenyl-methyl) - cyclohexane] - amine (2-methyl-1, 3-diphenyl-3-piperididin-1-il-propyl) - propyl amine, its preparation procedure, drug and drug synthesis containing these substances, And drugs for the treatment and / or prevention of pain, incontinence, pruritus, dinitrus aureum and / or diarrhea.