Use of Derivatives of M - amino phenyl imino imidazolidine for the preparation of medicaments for the treatment of incontinence of urine, Derivatives of M - amino phenyl imino imidazolidine with a New pattern of substituents on the phenyl ring, a process for their Preparation and the prepa

摘要

The use of m-amino-fenilamino-imidazolidina derivatives in general formula (1) or formula (2) was described,for the preparation of medicinal products for the treatment of urinary incontinence, in particular of stress incontinence, n where R1: F, Cl, Br, CH2F, CF2H or CF3, R2: NR6R7, with R6: Me, Et, iPr , R7: Me, Et, Pr or Pr, R3, R4, R5: are, in each case independently of each other, H, Me, F, Cl, Br, CH2F, CF2H and / or CF3 and, for the case in that R4 is Me, F, Cl, Br, CH2F, CF2H or CF3, then R1 is additionally also H or Me, and / or their pharmacologically compatible salts. The m-amino-phenylimino-imidazolidine derivatives of the general formula (1) or of the general formula (2) are also described,for the preparation of medicines, where R1: F, Cl, Br, CH2F, CF2H or CF3, R2: NR6R7, with R6: Me, Et, Pr or iPr, R7: Me, Et or Pr, R3, R4, R5 : they are, in each case independently of each other, H, Me, F, Cl, Br, CH2F, CF2H and / or CF3 and, in the case that R4 is Me, F, Cl, Br, CH2F, CF2H or CF3 , then R1 is additionally also H or Me, provided that R1 is neither chlorine nor bromine, and / or at least one of the radicals R4 or R5 is a substituent other than hydrogen,and / or its pharmacologically compatible salts. Procedures for the preparation of the above-mentioned compounds and the medicinal preparations containing them are also described. These compounds are alpha-1L agonists that selectively act on the bladder without substantially influencing the cardiocirculatory system and exhibit better properties in relation to bioavailability or metabolism.