Pirido compounds pirido - pyrrolo 3,2-g - and pirrolo 3,4 indole and pirido - pyrrolo 2,3 pirrolo 3,4-c carbazole, a process for their preparation, Pharmaceutical compositions containing compounds and Intermediates

摘要

Pyrido-pyrido-pyrrolo [3,2-g] pyrrolo [3,4-e] indole and pyrido-pyrrolo [2,3-a] pyrrolo [3,4-c] carbazole compounds of formula (1) in which : W1, W2 each represent, with the carbon atoms to which they are attached, a phenyl group or a pyridyl group; at least one of the groups W1 or W2 is understood to represent an identical or different pyridyl group, R1, R2, independently of each other,They represent a set of U-V formulas, where u represents a simple link or a C1-6 linear or branched asphalt chain, optionally replaced by one or more groups,Same or different, from halogen to hydrogen Xi, and / or optionally containing one or more unsaturated; V represents a group selected between hydrogen atom, halogen, cyanogen, nitrogen, azido, C1-6 linear tar or branched substance, arilo, C1-6 arilalquilo (wherein the tar part can be linear or branched substance).Hydroxy, alcoxi C1-6 linear or branched, ariloxi, arilalcoxi C1-6 (where alcoxi may be linear or branched);formyl, carboxy, aminocarbonyl, groups NR6R7, -C (O) -T1, -C (O) -NR6-T1, -NR6-C (O) -T1, -OC (O) -T1, -C (O) -O-T1, -O-T2-NR6R7, -O-T2-OR6, -O-T2-CO2R6, -NR6-T2-NR6R7, -NR6-T2-OR6, -NR6-T2-CO2R6 and -S ( O) t-R6, in which: R6 and R7, which may be the same or different, each represent a group selected from a hydrogen atom, a linear or branched C1-6 alkyl group, aryl and arylalkyl groups C1- 6 (in which the alkyl part can be linear or branched),O R6 + R7 and nitrogen atoms together form a single cycle or two cycle saturated heterocycle composed of 5 to 10 atoms. In the cycle system, the second selected abiotic atom is selectively contained. The choice between oxygen and nitrogen can be made by a group of C1-6 linear tar or 1. Branching, arilo, arilalquilo (C1-6), wherein the asphalt part is linear or branched, water Xi, alcoxi C1-6 linear or branched, ammonia water, monomer C1-6 linear or branched rented, and C1-6 cumin, each part of which can be linear or branched; T1 represents a group of C1-6 linear or branched asphalt, arilo,1. C-6 type arilalquilo C1-6, wherein the tar part is a linear or separated daughter, and a C1-6 type linear or separated daughter tar chain is selected from a group of substances selected from - or6, nr6r7, co2r6, C (o) R6 and C (o) nr6r7, wherein R6 and R7 are the substances defined above, And a linear or branched alquenileno c2-6 chain, replaced by a group of members selected from - or6, nr6r7, co2r6, C (o) R6 and - C (o) nr6r7, wherein R6 and R7 are the categories defined above; T 2 represents a linear or branched C1-6 asphalt chain; t represents an integer containing 0 to 2; R3 represents a group. Selected from the hydrogen atom1. C1-6 linear or branched C1-6 asphalt, arilo, arilalquilo C1-6 (wherein the asphalt part can be linear or branched);Cyclomethyldichloro, cyclomethylclara C1-6 (wherein the pitch part can be linear or branched),-Or6-nr6r7-o-t2-nr6r7-nr6-t2-nr6r7-nr6-t2-nr6r7, C1-6 oxyhydrogen tequila1. Di (hydroxy) C1-6 (each asphalt part can be linear or branched);-C (O) R6, -NH-C (O) R6, and a linear or branched C1-6 alkylene chain, substituted by one or more groups, identical or different, selected from halogen atoms, cyano, nitro groups, - OR6, -NR6R7, -CO2R6, -C (O) R6, linear or branched hydroxyalkylamino C1-6, di (hydroxyalkyl) amino C1-6 (in which each alkyl part can be linear or branched) and -C (O) -NHR6; groups R6, R7 and T2 have the same meanings as above; X represents a group selected from a hydrogen atom, and hydroxy, linear or branched C 1-6 alkoxy, mercapto and linear or branched C 1-6 alkylthio groups; Y represents a hydrogen atom, or X and Y form together,The carbon atom containing carbon atom is a group of carbon or sulfur carbides; X1 represents a group selected from the hydrogen atom, a group of hydrogen Xi, a linear or branched type of hydrogen oxygen C1-6, business opportunities and C1-6 linear or branched tar; Y1 represents a hydrogen atom, or X1 and Y1 are combined with carbon atoms. Carbon or sulfur carbide group; Q1 and Q2 represent hydrogen atom or Q1 and Q2, forming aromatic link with carbon atom carried by them; R4 represents a formula group (2),Among them: RA, Rb and RC, which may be the same or different, independent of each other,They represent a hydrogen atom, a halogen atom, a water Xi group, a C1-6 linear or separator group, ariloxi, arilalcoxi C1-6 (where the alcoxi part is linear or separator).1. C1-6 linear or branched tar, arilalquilo C1-6 (in which the tar part is linear or branched);Arilo, - nr6r7 (where R6 and R7 are the two types defined above),Azido, - n = N6 (where R6 is the above definition),Y-o-c (o) - R8, wherein R8 represents a linear or branched C1-6 hydrocarbon group (optionally replaced by one or more groups selected from halogen, hydroxyl, ammonia, C1-6 linear or branched lease and c1-6-6 diallamine), and each part can be linear or branched.Arilo, C1-6 arilalquilo (in which the tar part is linear or branched);Cyclopentadiene, or isocyclopropylene; RD represents a formaldehyde group or a u1-ra formula group, in which U1 represents a simple bond or more than one defined toluene and RA group; n is 0 or 1; R5 represents a group selected in the hydrogen atom, a C1-6 linear tar group or a branch group, C1-6 arilalquilo (in which the tar part is linear or branched);1. Arilsulfonilo, C1-6 are linear or branch C1-6 - and - C (o) - R6 (where R6 has the same meaning as above) or R4 and R5 jointly represent R4 and R5, provided that Q1 and Q2 together form an aromatic link, i.e. a set of formulas (3),Among them, carbon atom 1 is connected with nitrogen atom (a) in the cycle, and carbon atom 2 is connected with nitrogen atom (b) in the cycle;RA, Rb, RC and RD are defined as above; n is 0 or 1; its corresponding isomer and non corresponding isomer, and its added salt containing acid or acceptable basis of drug; arilo refers to a group of phenyl, northwest African, dihydrofluoroalkyl, tetrahydrofluoroalkyl, indenil or ind Nile River, Each group is replaced by one or more same or different groups selected from halogen, C1-6 linear tar or branch, C1-6 linear trihalotar or branch, hydroxyl, alcoxi C1-6 linear or branch.In addition, 1 or 2 groups of C1-6 linear tar or branched substance were selected to replace ammonia water. 1. Drug preparation procedures containing these substances and intermediates. Formula compounds (1) are useful as drugs. They are especially anti-tumor, so they are useful in the treatment of cancer.