Chimeric somatostatin analogues and dopamine, a Pharmaceutical formula using these analogues, for the preparation of a medicament

摘要

Dopamine synthesis in similar equation (1)X is H, CL, BR, I, F, -CN or C1-5 tar; R1 is H, tar, Alilo, C1-4 Alquenio, O-CN; R2 and R3 are H or not H, respectively, if R2 and R3 are not, there is a double connection between the carbon atoms to which they are connected; R4 is h or CH3; and es-o-,-C (O) -- yes.S- (CH2) s-C (O) --S (O) --S (O) 2--SC (O)..-OC (o)..-N (R5) - C (o) - o-n (R6) -; R5, R6, R7 and R8 are h, each of which is an independent C1-5 tar; R6 is h or C1-5 tar; m is 0 or 1; n is 0-10; L is - (CH) 2) P-C (o) -,When it's -S-S (O) --S (O) 2--O- o -N (R6) -I am a C (o) - (cr7r8) Q -,When it is - n (R6) -,-O-O-SI am... You areWhen it is - C (o)it is life.-OC (o)..-S- (CH2) s-C (O) - o -N (R5) -C (O) -P is 1-10; q is 2-4; s is 1-10; t is 1-10; Z is similar to somatostina or a group composed of - h-oh, alcoxyl (C1-6),Arilalcoxi, NH2, o-nr9r10, wherein R9 and R10 are independent h or C1-5 asphalt, or one of the pharmaceutically acceptable salts. 1. A compound of formula (2), wherein X is the tar of H, Cl, Br, I, F, - CN or C1-5; R1 is the tar of C1-4, h, alilo, alquenilo or CN; R2 and R3 are h or h respectively, or in the absence of R2 and R3, there is a double-layer link between the attached carbon atoms; R4 is h or CH3; R5 is a set of C1-5 tar, or a set of - (CH2) Rn (CH3) Q formulas; and is - or--C (O) -- yes.-SC (O)..-OC (o)..-N (R6) -C (O) --N (R7) - o -N (R8) - (CH2) s-C (O) -R6, R7, R8, R9 and R10 are h, each of which is an independent C1-5 tar; L is - (CH2) P-C (o) -.When it's -S-O- o -N (R7) -L es -C (O) - (CR9R10) q-C (O) -When it's - n (R7) -,-O-O-SI am... You areWhen it is - C (o)it is life.-OC (o)..-N (R8) - (CH2) s-C (O) - o -N (R6) -C (O) -M equals 0 or 1; n equals 2-10; R equals 1-8; Q equals 2-4; P equals 1-10; s equals 1-10; t equals 1-10; and Z is similar to somatostina or a group composed of - h-oh, alcoxi C1-6, arilalcoxilo, NH2, o-nr9r10 or one of the pharmaceutically acceptable salts, which maintain monomer and dopamine activity. An example is: 6-n-propil-8b-energetically methodical-d-phe-c (cys-tyr-d-trp-lys-abu-cys) - thr-nh2. It also describes the formulation and composition of a drug, as well as the use of these similar substances in the production of drugs for the treatment of lung cancer, blood cells, anorexia, hypothyroidism, hypertension, H.pylori diffusion, acrylonitrile, restenosis.Crohn's disease, systemic sclerosis, pseudocyst and internal and external pancreatic cyst, tumor, Nestle tumor, multiple insulin, gastric tumor, zoellinger Ellison syndrome, diarrhea, AIDS related diarrhea, chemotherapy-related diarrhea, sclerosis, irritable bowel syndrome, pancreatitis, Intestinal obstruction, gastrointestinal reflex, gastrointestinal reflex, gastrointestinal recession, gastric syndrome, gonorrhea, hyperthermia of thyroid, acute disease, diabetic neuropathy, Paget disease, polycystic ovarian disease, thyroid cancer, hepatoma, leukemia, meningitis, cancer caxia, static hypotension, Hypotension after prandiaPanic attack, adenoma GH secretion, acrylonitrile, adenoma TSH secretion, adenoma prolactina secretion, insulin deficiency, diabetes, insulin deficiency, syndrome X, vascular disease, proliferative retinopathy, dawn phenomenon, kidney disease, gastric secretion, Pelvic ulcer, intestinal fistula, pancreatitis, rapid vacuum syndrome, water diarrhea syndrome, pancreatitis, gastrointestinal hormone secreting tumor, angiopathy, arthritis, rejection of aloe vera, transplant blood vessel bleeding, hypertension, gastrointestinal bleeding, Obesity and drug overdose.