Methods for assessing parameters associated with a systemic vasculature condition or event and the extent of an infarction or related condition in an individual, arrangement of binding partners for elements in an individual's biological sample, data processing device for assessing a systemic vasculature condition or event, program product and computer system, and treatment method

摘要

"METHODS FOR ASSESSING PARAMETERS ASSOCIATED WITH A SYSTEMIC VASCULATURE CONDITION OR EVENT AND THE EXTENSION OF A RELATED INFRINGEMENT OR CONDITION, ARRANGEMENT OF CONNECTION PARTNERS FOR AN INDIVIDUAL DEVELOPMENT PROVISIONS A CONDITION OR EVENT OF THE SYSTEMIC VASCULATURE, PRODUCT PRODUCT AND COMPUTER SYSTEM AND TREATMENT METHOD ". The present invention generally relates to a diagnostic device including a prognostic test for parameters that are indicative of a condition or event associated with systemic vasculature. More particularly, the present invention provides a test for detecting parameters associated with a vascular disease including generalized cardiovascular, stroke, pulmonary, renovascular, cerebrovascular, thrombotic, or arterial or venous condition or event, including acute coronary syndrome such as, but not limited to acute myocardial infarction, heart failure, atheromoma or a thrombotic condition. Identifying these parameters or more particularly a parameter pattern allows the diagnosis of a condition or event or the determination of the risk of developing a condition or event associated with the systemic vasculature. Even more particularly, the present invention is directed to a diagnostic device comprising a set of elements wherein one or more of said elements have or have specific or generic binding partners in a biological sample from an animal including a human subject, wherein the The pattern of binding of the elements to the binding partners is indicative, predictive or otherwise associated with the possibility of a condition or event within the systemic vasculature. The absence of detection of specific or generic binding partners is also of indicative or predictive value. This is particularly important in cases where patients are unable to communicate to a physician aspects of their own condition, such as during surgery or for comatose patients. It is also usable in determining the risk of vascular disease including generalized cardiovascular, stroke, pulmonary, renovascular, cerebrovascular, thrombotic, or arterial or venous conditions or events in a healthy individual or an individual entering a risk exposure such as surgery or chemotherapy. The present invention is useful, inter alia, for the identification and / or quantification of biochemical markers of conditions or events in systemic vasculature such as heart disease, heart disorders, heart infections, stroke and thrombosis as well as determining a risk. of development of these conditions including absence of disturbance or absence of risk of development of a disorder. The assessment of this condition can be done in a clinical setting as part of the screening, as part of routine testing protocol and / or as a laboratory procedure.