Derivative of an insulinotropic peptide and pharmaceutically acceptable salts produced therefrom, method of producing insulinotropic peptide derivative and use of an insulinotropic peptide derivative and pharmaceutically acceptable salts.

摘要

"Derivative of an Insulinotropic PEPTIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS PRODUCED FROM THE SAME, METHOD OF PRODUCTION OF INSULINOTROPIC INSULINOTROPIC PEPTIDE AND USE OF A PHARMACEUTICAL INSULINOTROPIC PEPTIDE. The present invention relates to derivatives of an Exendin-4 insulinotropic peptide and pharmaceutically acceptable salts thereof, which are useful for the treatment of type II diabetes. Exendin-4 has a chemical structure as shown below: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-X-Glu-Glu-Glu -Ala-Val- YLeu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Gly-Ala-Pro-Pro-Ser-Z where: X represents Arg, Leu or Ile, Y represents His, Arg or Lys and Z represents Arg-OH, -OH, -NH-2 ~ or Lys-OH. The derivatives of the present invention may be prepared by chemical synthetic means and, more easily, by recombinant techniques, which makes commercial production possible.