A process for the preparation of a particulate material, methods for controlled agglomeration of a finely dispersed solid material, for improving the bioavailability of a therapeutic and / or prophylactically active substance, and for improving the shelf life of a pharmaceutical composition, articulated material, composition. pharmaceutical, use of a vehicle, pharmaceutical particulate matter, and use of magnesium aluminosilicate and / or magnesium aluminomethyl silicate

摘要

"PROCESS FOR THE PREPARATION OF A PARTICULAR MATERIAL, METHODS FOR CONTROLLED AGGLOMERATION OF A FINALLY DISPERSED SOLID MATERIAL, TO IMPROVE THE BIODISPONIBILITY OF A THERAPEUTIC ACTIVE SUBSTANCE, AND TO IMPROVE PARTICULARLY MATERIALS PHARMACEUTICAL COMPOSITION, USE OF A VEHICLE, PARTICULAR PHARMACEUTICAL MATERIAL, AND USE OF MAGNESIUM ALUMINOSILICATE AND / OR MAGNESIUM ALUMINOMETASSILICATE ". A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables controlled growth of particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutic and / or prophylactically active substance which has a relatively low aqueous solubility and / or which is subject to chemical decomposition. The process comprising i) spraying a first composition comprising a carrier having a melting point of about 5 ° C or more which is present in the first liquid form composition into a second composition comprising a solid form material , the second composition having a temperature of at most corresponding to the melting point of the vehicle and / or vehicle composition and (ii) mixing or other means of mechanically working the second composition, on which the first composition is sprayed, to obtain the material. particulate matter.