Innovative compounds that are potent inhibitors of the + / ca2 + exchange mechanism and are useful in the treatment of arrhythmias.

摘要

"INNOVATIVE COMPOUNDS THAT ARE POWERFUL INHIBITORS OF THE ^ + ^ / Ca ^ 2 + ^ EXCHANGE MECHANISM AND ARE USEFUL IN ARRYTHMA TREATMENT" Therapeutically active compounds of formula (I) are described: where X is -O-, -CH-2 ~ - or -C (O) -; Z is - CHR ~ 9 ~ - or valence bond; Y is -CH ~ 2 ~ -, -C (O) -, CH (OR ~ 10 ~) -, -CH (NR ~ 11R ~ 12 ~) -, -O-, -S-, -S (O) - or -S (O ~ 2 ~) -, provided that when Z is a valence bond, Y is not C (O); the dotted line represents an optional double bond, in which case Z is -CR ~ 9 ~ - and Y is -CH-, C (OR ~ 10 ~) -, or -C (NR ~ 11 ~ R ~ 12 ~) - ; R ~ 1 ~ is - (CH ~ 2 ~) ~ n ~ NR ~ 4 ~ R ~ 7 ~ or one of the following groups: n is 1 - 4, R ~ 2 ~ and R ~ 3 ~ are independently H, lower alkyl , lower alkoxy, -NO ~ 2 ~, halogen, -CF ~ 3 ~, -OH, -NHR ~ 8 ~ or -COOH, R @ 4 and R @ 7 ~ are independently H, lower alkyl or hydroxy-lower alkyl R5 is H, lower alkoxy, -CF3-, -NH2- or -CN; R ~ 6 ~ is -NO ~ 2 ~, -NR ~ 14 ~ R ~ 19 ~, -CF ~ 3 ~ or R ~ 8 ~ and R ~ 16 ~ are independently H or acyl, R ~ 9 ~ is H or alkyl lower, R10 is H, alkylsulfonyl or acyl; R 11 and R 12 are independently H, lower alkyl or acyl, R 13 and R 18 are independently H or -OR 20, R 14 and R 19 are independently H, acyl, alkylsulfonyl, C (S) NHR ~ 17 ~ or C (O) NHR ~ 17 ~, R ~ 15 ~ is H or NH ~ 2 ~, R ~ 17 ~ is H or lower alkyl, R ~ 20 ~ is H or acyl, and its salts and esters for pharmaceutical purposes. The compounds are potent inhibitors of the Na ^ + ^ / Ca ^ 2 + ^ exchange mechanism.