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Carbamate compounds for use in the prevention or treatment of neuropathic pain and cluster and hemicranial headache pain

机译:氨基甲酸酯化合物,用于预防或治疗神经性疼痛,丛集性和半颅性头痛

摘要

"CARBAMATE COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NEUROPATHIC PAIN AND PAIN ASSOCIATED PAIN IN HEAD AND HEMICRANIA". The present invention relates to a method for preventing or treating neuropathic pain and cluster and hemicranial headache pain comprising administering to a subject in need thereof a therapeutically effective amount of a Formula (I) enantiomer substantially free of other disorders. enantiomers or an enantiomeric mixture where a Formula (I) enantiomer predominates: where phenyl is substituted at X by one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1-1 and R2 are independently selected from the group consisting of hydrogen and C1-4 alkyl; where C 1 - C 4 -C 4 alkyl is optionally substituted by phenyl (where phenyl is optionally substituted by substituents independently selected from the group consisting of hydrogen, halogen, C 1 -C 4 alkyl, C 1 - C 1-4 alkoxy, amino, nitro and cyano).
机译:“用于预防或治疗头部和血友病的神经性疼痛和疼痛相关疼痛的氨基甲酸酯化合物”。本发明涉及一种预防或治疗神经性疼痛和丛集性及半颅性头痛的方法,该方法包括向有需要的受试者施用治疗有效量的基本上无其他病症的式(I)对映体。其中式(I)对映体占优势的对映体或对映体混合物:其中苯基在X处被1-5个独立地选自氟,氯,溴和碘的卤素原子取代;和; R1-1和R2独立地选自氢和C1-4烷基;其中C 1 -C 4 -C 4烷基任选地被苯基取代(其中苯基任选地被独立地选自氢,卤素,C 1 -C 4烷基,C 1 -C 1-4烷氧基的取代基取代,氨基,硝基和氰基)。

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