3-Phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-dione bisulfate salt, pharmaceutical composition, use of a 3-phenyl-3-dimethylaminoalkyl-4,4-bisulfate salt -dimethylpiperidin-2,6-dione, and method for the treatment or prophylaxis of a stress-related affective disorder

摘要

"3-Phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidine-2,6-diana bisulfate salt, pharmaceutical composition, use of a 3-phenyl-3-dimethylamino-alkyl-4-bisulfate salt, 4-DIMETHYPYPERIDIN-2,6-D IONA, AND METHOD FOR TREATMENT OR PROPHYLAXIS OF A VOLTAGE-RELATED AFFECTIVE DISORDER ". The novel bis-sulfate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-diones and pharmacologically acceptable solvates thereof are devoid of weight loss and hepatocyte changes in the rat which have been limited to levels. marginally effective clinical allowable doses of the corresponding chlorides in the treatment or prophylaxis of affective tension-related disorders such as anxiety, depression, migraine and sleep apnea. Preferred bisulfate salts are 3- (3,5-dimethoxyphenyl) -3- (3-dimethylaminopropyl) 4,4-dimethylpiperidine-2,6-dione bisulfate and especially 3- (3-methoxyphenyl) bisulfate -3- (3-dimethylaminopropyl) -4,4-dimethylpiperidine-2,6-dio.