首页>
外国专利>
Use of one-dimensional nuclear spin resonance for the identification of ligands for target biomolecules
Use of one-dimensional nuclear spin resonance for the identification of ligands for target biomolecules
展开▼
机译:一维核自旋共振在鉴定目标生物分子配体中的用途
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides a process for identifying compounds which bind to a specific target molecule. The process comprises the steps of: a) generating a first T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating a second T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed the target molecule in step (b); and d) comparing said first and second T2- or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.
展开▼