THE PROCESS FOR MANUFACTURING FORMULATION OF TOPICAL BETA-BLOCKERS WITH IMPROVED EFFICACY

摘要

1. A process of manufacturing of formulation of topical beta-blockers with improved efficacy comprising the following steps: i) a. Making aqueous solution of Beta-blocker with or without physiologically acceptable excipients, buffers and preservatives with defining pH and adjusting it if needed. b. Making a gel of known gel forming substance with or without physiologically excipients buffers and preservatives in a separate vessel, with defining pH and adjusting it if needed. ii) Adding aqueous solution of Beta-blockers at step i (a) into a prepared gel of step i (b) while stirring slowly. iii) Adjusting the pH and volume before finally autoclaving and packaging. 2. A process as claimed in claim 1, wherein Beta-blockers can be selected from topical Beta-blockers used to reduce intraocular pressure, e. g. Timolol, Betaxolol, Carteolol, Metipranalol. 3. A process as in claim 1 to 2, wherein concentration of carbopol can be from 0.5% to 5%. 4. A process as claimed in claim 1 to 3, in which physiologically acceptable buffers, excipients and preservatives are used. 5. A process as claimed in claim 1 to 4, wherein pH of formulation is finally adjusted to 6.0 to 8.0 preferably between 6.5 and 7.5. 6. A process as claimed in claim 1 to 5, wherein formulation is autoclaved before packaging.