triamiidasendatud indoolid, bensofuraanid and bensotiofeenid microsomal triglyceride transport protein (mtp) when and / or apolipoprotein b (apob) secretion inhibitors

摘要

The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.