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extended release solid pharmaceutical form of regulated / dose dumping if the reduced risk, a new drug delivery system
extended release solid pharmaceutical form of regulated / dose dumping if the reduced risk, a new drug delivery system
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机译:缓释固体药物形式的调节剂量/剂量转移,如果降低了风险,则采用新的药物输送系统
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摘要
A sustained/controlled release formulation with reduced risk of dose dumping and side effects combines two components: component (a) comprises a pharmaceutically active agent and a water-insoluble, but water-permeable polymer, whereas component (b) comprises a pharmaceutically active agent and a hydrophobic material. By changing the ratio of a pharmaceutically active agent and water-insoluble, but water-permeable polymer comprised in the component (a) and/or the ratio of the pharmaceutically active agent and hydrophobic material comprised in the component (b), and ideal release rate, with reduced risk of dose dumping and side effects, can easily be achieved.
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