PEROXISIME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST TRIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE

摘要

The present invention relates to compounds of formula (I) which act as agonists on peroxisome proliferator activated receptors and as such are useful in the treatment and prevention of diabetes mellitus, cardiovascular disease, obesity, inflammatory bowel disease, among others. The invention also relates to pharmaceutical compositions containing the compounds of formula (I). Substituents of formula (I) have a variety of meanings, such as (a) R 1 is hydrogen, optionally substituted, which is optionally alkyl, aryl (C 0-4) alkyl, heteroaryl (C0-4) alkyl, ( C3-6cycloalkyl) arylC0-2alkyl and phenyl; (b) W is O or S; (c) R2 is hydrogen or an optionally substituted group selected from alkyl, allyl, arylC0-4alkyl, heteroarylC0-4alkyl, and C3-6cycloalkyl; (d) X is an optionally substituted C 1 -C 5 alkylene linker, wherein one of the carbon atoms of the linker may be replaced by O, NH or S. (e) Y is C, O, S, NH or a single bond; and (f) is hydrogen, C (R 3) (R 4) A, A, optionally substituted, optionally (CH 2) n COOR 19, alkyl, allyl, aryl (C 0 -C 4) alkyl, thio (1-4); C 1-4 -alkyl, thioaryl, alkoxy-aryl, C 1-4 -alkoxy-C 1-4 -alkyl, amino-aryl and amino-C 1-4 -alkyl, wherein (i) ) n is 0, 1, 2 or 3; (ii) A is a functional group selected from carboxyl, (C 1 -C 3) alkyl, nitrile, carboxamide, substituted or unsubstituted sulfonamide, substituted or unsubstituted acylsulfonamide, and substituted or unsubstituted tetrazolyl; (iii) R 3 is hydrogen, saturated or unsaturated C 1 -C 5 alkyl, C 1 -C 5 alkoxy, and (iv) R 4 is hydrogen, halogen, substituted or unsubstituted alkyl, alkoxy, C 3 -C 6 cycloalkyl, aryl; - (C 0 -C 4 alkyl) and phenyl, or R 3 and R 4 together may form a C 3 -C 4 cycloalkyl group; SHE