BIODEGRADABLE MICROPARTICLES FOR CONTROLLED RELEASE ADMINISTRATION, WITH PURIFIED AMYLOPECTIN-BASED STARCH OF REDUCED MOLECULAR WEIGHT

摘要

A process for the preparation of microparticles for parenteral administration by preparing an aqueous solution of at least 20% by weight of purified molecular weight reduced amylopectin-based starch, mixing the solution with a biologically active substance, forming a starch droplet emulsion into an outer phase polymer solution Optionally, a release control shell is applied to the particles. The invention also relates to microparticles which consist essentially of the starch in question, have an amino acid content of less than 50 mg and lack covalent chemical crosslinks. SHE