COMPOSITION FOR PREVENTION AND TREATMENT OF HIV-1 INFECTION COMPRISING AT LEAST TWO DIFFERENT HIV-1 REVERSE TRANSCRIPTASE INHIBITORS

摘要

The present invention provides a composition for the prevention or treatment of HIV-1 infections which comprises a) a first HIV-1 reverse transcriptase inhibitor compound of formula (I) wherein X1 is oxygen or sulfur; Q is -C (R3) NOR4 or -COYR5; Yoxygen or sulfur; R1 is halogen; R2 is hydrogen, C1-4alkyl; R3 is hydrogen; R4 is C3-C6 alkyl; and R 5i) C 3-7 cycloalkyl optionally substituted with one or more C 1-4 alkyl groups; or ii) (a) a group of the general formula wherein R 6 is hydrogen or a straight or branched C 1-6 alkyl group; and R7 and R8 are hydrogen; and b) a second HIV-1 reverse transcriptase inhibitor compound that is not selected by the same one or more HIV-1 mutant strains as the first HIV-1 reverse transcriptase inhibitor compound of a); and the weight ratio of the first HIV-1 reverse transcriptase inhibitor compound to the second HIV-1 reverse transcriptase compound is between 100: 1 and 1: 100. ŕ