1, 6-DISUBSTITUTED-1H- PYRAZOLO 3, 4-d - PYRIMIDIN-4 (5H) - ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

1, 5-Dihydro-pyrazolo [3, 4-d] pyridimidinone derivatives of the formula in which A and D together represent a radical of the formula 3425 ט" ז בשבט התשס" ד - February 8, 2004 where R2 represents aryl which has 6 to 10 carbon atoms and which is optionally up to trisubstituted by identical or different substituents from the series consisting of nitro, cyano, hydroxyl, trifluoromethyl, halogen, carboxyl, or by straight-chain or branched acyl, alkoxy or alkoxycarbonyl, each of which has up to 6 carbon atoms or hydrogen, trifluoromethyl, cyano, carboxyl, or straight-chain or branched alkoxy or alkoxycarbonyl, each of which has up to 8 carbon atoms, or straight-chain or branched alkyl which has up to 8 carbon atoms and which is optionally substituted by hydroxyl, R1 represents straight-chain or branched acyl having up to 4 carbon atoms, or represents straight-chain or branched alkyl having up to 10 carbon atoms, optionally subsituted by hydroxyl, azido or by a group of the formula -NR3R4 or -OSO2R5 where R3 and R4 are identical or different and represent hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms, or R3 and R4 together with the nitrogen atom form a 5 or 6-membered saturated heterocycle which can optionally contain a further hetero atom selected from the series consisting of S or O or a radical -NR6 where R6 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms and R5 represents phenyl or straight-chain or branched alkyl having up to 5 carbon atoms, E represents a straight-chain or branched alkylene or alkenylene chain, each of which has up to 6 carbon atoms which are optionally substituted by hydroxyl, or represents the C=O group, L and V are identical or different and represent aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused, heterocycle which has up to 3 hetero atoms from the series consisting of S, N and/or O which are optionally up to trisubstituted by identical or different substituents from the series consisting of halogen, hydroxyl, nitro, trifluoromethyl, carboxyl, straight-chain or branched alkyl, alkoxy or alkoxycarbonyl, each of which has up to 6 carbon atoms, or by a group of the formula- (W)a-NR7R8 where a and b are 0 or 1, W is a radical of the formula -CO or -SO2, R7 and R8 are identical or different and have the abovementioned meaning of R3 and R4, and/or the cycles are optionally substituted by aryl having 6 to 10 carbon atoms or by a 5-to 7-membered aromatic, optionally benzo-fused, heterocycle having up to 3 betero atoms from the series consisting of S, N and/or O, which, in turn, are optionally up to disubstituted by identical or different substituents from the series consisting of halogen, hydroxyl, nitro, carboxyl, trifluoromethyl or by straight- chain or branched alkyl, alkoxy or alkoxycarbonyl, each of which has up to 5 cabron atoms, or by a group of the formula -(W')b-NR9R10 where b has the abovementioned meaning of a and is identical to this meaning or different from it, R9 and R10 have the abovementioned meaning of R3 and R4 and are identical to this meaning or different from it, W' has the abovementioned meaning of W and is identical to this meaning or different from it, or L represents a radical of the formula 3426 ט" ז בשבט התשס" ד - February 8, 2004 T represents a radical of the formula -CH2-X-Y- where X represents a bond or an oxygen or sulphur atom or the -NH-group, Y represents a straight-chain or branched alkylene chain having up to 9 carbon atoms, and the tautomers and salts of these.