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COMPLEX FORMATION BETWEEN dsDNA ANDOLIGOMER OF HETEROCYCLES
COMPLEX FORMATION BETWEEN dsDNA ANDOLIGOMER OF HETEROCYCLES
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机译:dsDNA与杂环寡聚体之间的复杂形成
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摘要
Methods and compositions are provided for forming complexes between dsDNA and oligomers of heterocycles, aliphatic amino acids, particularly omega-amino acids, and a polar end group. By appropriate choice of target sequences and composition of the oligomers, complexes are obtained with low dissociation constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or expression of undesired genes.
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