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MULTIVALENT MENINGOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE FOR USE IN PROTECTING A HUMAN AGAINST INFECTION BY N.MENINGITIDIS AND A METHOD FOR PREPARING SUCH A VACCINE
MULTIVALENT MENINGOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE FOR USE IN PROTECTING A HUMAN AGAINST INFECTION BY N.MENINGITIDIS AND A METHOD FOR PREPARING SUCH A VACCINE
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机译:多价脑膜炎球菌多糖蛋白联合疫苗,用于保护人脑膜炎奈瑟氏球菌感染和制备这种疫苗的方法
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摘要
The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacterial Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults,
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