USE OF PIPERAZINE QUINOLINONE AND PIPERAZINE QUINOLINTHIONE DERIVATIVES IN THE PREPARATION OF MEDICAMENTS FOR REDUCING MACROPHAGE MIGRATION INHIBITORY FACTOR ACTIVITY

摘要

Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: (Ia) (Ib) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.