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ANTIGEN ARRAYS PRESENTING IL-5, IL-3, OR EOTAXIN FOR TREATMENT OF ALLERGIC EOSINOPHILIC DISEASES
ANTIGEN ARRAYS PRESENTING IL-5, IL-3, OR EOTAXIN FOR TREATMENT OF ALLERGIC EOSINOPHILIC DISEASES
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机译:呈现IL-5,IL-3或EOTAXIN的抗原阵列可治疗过敏性嗜酸性疾病
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摘要
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
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