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METHODS FOR REGULATING A CELL-MEDIATED IMMUNE BY BLOCKING LYMPHOCYTIC SIGNALS AND BY BLOCKING LFA-1 MEDIATED ADHESION
METHODS FOR REGULATING A CELL-MEDIATED IMMUNE BY BLOCKING LYMPHOCYTIC SIGNALS AND BY BLOCKING LFA-1 MEDIATED ADHESION
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机译:通过阻止淋巴细胞信号和通过LFA-1介导的粘附来调节细胞介导的免疫的方法
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摘要
The invention provides methods for regulating cell-mediated immune responses, immune system diseases and allograft transplant rejection by interfering with the interaction of at least three different cell surface molecules with their natural ligands. A first cellular interaction is mediated by CD28/B7/CTLA4, a second interaction is mediated by CD40/CD154, and a third interaction is mediated by LFA-1 interaction with its ligands. Regulation of a cell-mediated immune response affects immune system diseases such as those associated with allograft transplantation.
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