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NEW RIBOSOMAL L1 PROTEIN GENE FROM CORYNEFORM BACTERIA, USEFUL, WHEN DOWNREGULATED, FOR INCREASING FERMENTATIVE PRODUCTION OF AMINO ACIDS.
NEW RIBOSOMAL L1 PROTEIN GENE FROM CORYNEFORM BACTERIA, USEFUL, WHEN DOWNREGULATED, FOR INCREASING FERMENTATIVE PRODUCTION OF AMINO ACIDS.
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机译:降级配方时,有用的时候从菜形细菌中提取新的核糖体L1蛋白基因,以提高氨基酸的发酵产量。
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摘要
Isolated nucleic acid (I) from coryneform bacteria which is at least 70% identical with a sequence that encodes a 145 amino acid (aa) polypeptide (II) fully defined in the specification, encodes a polypeptide at least 70% identical with (II), its complement or contains at least 15 consecutive bases of (I). Independent claims are also included for the following: (1) vector containing (I), deposited in Escherichia coli DH5 alpha /p DELTA rpk, as DSM 13158 (map reproduced in specification); (2) as host cells, coryneform bacteria that have a deletion or insertion in the rplk gene; and (3) method (M1) for producing L-aa, especially lysine, by fermenting bacteria in which at least the rplk gene has been weakened.
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机译:从棒状细菌中分离的核酸(I)与编码本规范中完全定义的145个氨基酸(aa)多肽(II)的序列至少70%同一性,编码与(II)至少70%相同的多肽,其补语或包含(I)的至少15个连续碱基。还包括以下方面的独立权利要求:(1)包含(I)的载体,其作为DSM 13158保藏在大肠杆菌DH5α/ p DELTA rpk中(在说明书中复制的图); (2)在rplk基因中缺失或插入的棒状细菌作为宿主细胞; (3)通过发酵至少其中rplk基因已被弱化的细菌来生产L-aa,特别是赖氨酸的方法(M1)。
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