PYRIDINIUM DERIVATIVES FOR THE MANAGEMENT OF AGINGRELATED AND DIABETIC VASCULAR COMPLICATIONS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF.

摘要

The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and agingrelated vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discoloration of teeth, by breaking preformed AGE, of general formula (I), or pharmaceutically acceptable salts thereof, wherein, R 1, R 2, R 3, X and m are as defined in the specification. The invention also discloses, method for preparation of the novel compounds of the series and pharmaceutical composition having one or more compounds as defined above as active ingredients. The invention further discloses a method of treatment of a diabetic patient by administering the compounds as defined above, either singly or in combination with drugs for antidiabetic therapy.