首页> 外国专利> NEW COMPOUND 2R -(2R*, 3S*, 4R*, 5R*, 8R*, 10R*, 11R*, 12S*, 13S*, 14R*)-13 -(2, 6- DIDEOXY 3-C-METHYI -3 -O-METHYL -A-L-RIBO -HEXOPYRANOSYL) OXY-2-ETHYL-3, 4, 10- TRIHYDROXY -3, 5, 6, 8, 10, 12, 14-HEPTAMETHYL -11-3, 4, 6-TRIDEOXY-3-(DIMETHYLA

NEW COMPOUND 2R -(2R*, 3S*, 4R*, 5R*, 8R*, 10R*, 11R*, 12S*, 13S*, 14R*)-13 -(2, 6- DIDEOXY 3-C-METHYI -3 -O-METHYL -A-L-RIBO -HEXOPYRANOSYL) OXY-2-ETHYL-3, 4, 10- TRIHYDROXY -3, 5, 6, 8, 10, 12, 14-HEPTAMETHYL -11-3, 4, 6-TRIDEOXY-3-(DIMETHYLA

机译:新化合物[2R-(2R *,3S *,4R *,5R *,8R *,10R *,11R *,12S *,13S *,14R *)]-13-[(2,6- DIDEOXY 3-C -甲基-3 -O-甲基-AL-RIBO-六氢呋喃基)[OXY] -2-ETHYL-3,4,10-三羟基-3,5,6,8,10,12,14-庚基-11-[[ 3,4,6-三氟-3-(二甲基

摘要

Provided herein is a new compound [2R -(2R*, 3S*, 4R*, 5R*, 8R*, 10R*, 11R*, 12S*, 13S*, 14R*)]-13 -[(2, 6-Dideoxy -3-C-methyI -3 -O-methyl a-L-ribo -hexopyranosyl)oxy] -2-ethyl-3, 4, 10- trihydroxy -3, 5, 6, 8, 10, 12, 14-heptamethyl -11-[[3, 4, 6-trideoxy -3-(dimethylamino) -'-D-xyl -hexopiranosil] oxy]-1-oxa-6 -azacyclopentadecan -15-one or with name of IUPAC 9- deoxo-9a -aza-9a -methyl-9a- homoerythromycin A and which is elucidated, for diverse physicochemical methods, which correspond with the and anhydrous and crystaline form with a tetragonal crystaline system, with spatial group P42212, cell constants a= 14.452 A0, b = 14.452 A0, c = 41.645 A0 and volume 8698 A03. Also herein is depicted the process for obtaining it starting from the amorphous forms, monohydrate, dehydrate, from its salts, from another by-product, from another polymorphous or pseudopolymorphous forms.
机译:本文提供了新化合物[2R-(2R *,3S *,4R *,5R *,8R *,10R *,11R *,12S *,13S *,14R *)]-13-[(2,6-二脱氧-3-C-甲基I -3 -O-甲基aL-核糖-己吡喃糖基)氧基] -2-乙基-3,4,10-三羟基-3,5,6,8,10,12,14-七甲基- 11-[[[3,4,6-三苯氧基-3-(二甲基氨基)-'- D-二甲苯基己吡喃氧基]氧基] -1-oxa-6-氮杂环十五烷-15-15或具有IUPAC 9- deoxo-9a -aza-9a-甲基-9a-同型红霉素A,已针对多种物理化学方法进行了阐明,分别对应于四方晶系的无水和结晶形式,空间群为P42212,细胞常数a = 14.452 A0,b = 14.452 A0,c = 41.645 A0和体积8698 A03。本文还描述了从无定形形式,一水合物,脱水物,其盐,另一副产物,另一多晶型或假多晶型形式获得它的方法。

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