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Novel derivatives of 3-amido chromanylosolphonylurea and 3-amido chromanylothiosulphonylurea, method of obtaining them, their application in production of pharmaceutic agents and pharmaceutic agent as such
Novel derivatives of 3-amido chromanylosolphonylurea and 3-amido chromanylothiosulphonylurea, method of obtaining them, their application in production of pharmaceutic agents and pharmaceutic agent as such
3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.
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机译:具有所有立体异构体(或混合物)形式的式(I)的3-氨基-苯并氨磺酰基-脲或-硫脲衍生物,以及它们的盐是新的。 R1 = H,烷基,烷氧基,烷氧基烷氧基,烷硫基,F,Cl,Br,I或CF3; R2 = H,Me或Et; R3 = H或烷基; Z = O或S; A =苯基(可被1-3个卤素,Me,Et,OMe或OEt取代),式(i)的内酰胺残基,1-氧代-1,2,3,4-四氢异喹啉-2-基,1-氧代-全氢异喹啉-2-基,1-氧代-2,3-异吲哚啉-2-基或1-氧代全氢异吲哚啉-2-基; B = 3-6C亚烷基或3-6C亚烯基(均任选被1-3个烷基取代);所有烷基部分均具有1-4C。
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