Methods for modulating NFkB activity and for identifying modulators of NFkB using TPL-2

摘要

A method for identifying a compound capable of modulating the activity of p105, whereby a TPL-2 molecule (a regulator of the degradation of p105) is incubated with said compound and identified if TPL-2 activity is influenced. Such compounds are capable of modulating the NFêB pathway, and thus have use in treating TPL-2-mediated NFêB regulation disorders.