Modulating prolactin receptors to affect a physiological response

摘要

A method for affecting a physiological response of a non-human animal to circulating levels of prolactin and/or prolactin mimetics. The method is characterized by modulating prolactin receptors by effectively signaling a sustained increase in the circulating level of prolactin and/or prolactin mimetics, followed by a decrease back to normal or low levels. The levels of circulating prolactin may also be increased by incorporating into a non-human animal's genome an inducible recombinant nucleotide sequence encoding biologically active prolactin.