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Peptide mimics of conserved gonococcal epitopes and methods and compositions using them for immunizing against Neisseria gonorrhoeae
Peptide mimics of conserved gonococcal epitopes and methods and compositions using them for immunizing against Neisseria gonorrhoeae
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机译:保守的淋球菌抗原决定簇的肽模拟物以及使用其模拟淋病奈瑟菌的方法和组合物
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摘要
A peptide mimic of a conserved gonococcal epitope not found on human blood group antigens and capable of inducing in a mammal an immune response against the conserved gonococcal epitope comprises the amino acid sequence DE_GLF. Also described is a peptide mimic which immunospecifically binds to an antibody that binds to an oligosaccharide of N. gonorrhoeae, which epitope is not present in human blood group antigens and comprises the amino acid sequence DE_GLF. The peptide mimic can further bind the monoclonal antibody 2C7. A composition for immunizing against an N. gonorrhoeae infection can comprises the peptide mimics described above or the peptide mimics comprising the sequence of SEQ ID NO:1-6 and 10. The peptide mimic can be further coupled to the complement protein C3d which increases the antigenicity of the peptide mimic.
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机译:在人血型抗原上未发现的并且能够在哺乳动物中诱导针对保守的淋球菌抗原决定簇的免疫应答的保守的淋菌球抗原决定簇的肽模拟物包含氨基酸序列DE_GLF。还描述了一种肽模拟物,该肽模拟物与抗体结合,该抗体与淋病奈瑟氏球菌的寡糖结合,该抗原决定簇在人血型抗原中不存在,并且包含氨基酸序列DE_GLF。肽模拟物可以进一步结合单克隆抗体2C7。免疫淋病奈瑟氏球菌感染的组合物可包含上述肽模拟物或包含SEQ ID NO:1-6和10的序列的肽模拟物。该肽模拟物可进一步偶联至补体蛋白C3d,该补体蛋白C3d增加肽模拟物的抗原性。
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