Heterocyclic compounds having an inhibitory activity on calpains or a trapping activity on reactive oxygen species (ROS's) and their use as medicines

摘要

Heterocyclic derivatives having a calpain inhibiting activity and/or an activity trapping reactive oxygen species, of formula (I) are disclosed, wherein A, X, Y, R1, R2 and Het represent variable groups as described in the specification, with the exception that when Het represents tetrahydrofuran or tertahydropyran, R1 represents the OR3 radical wherein R3 is H, alkyl, arylalkyl, heterocycloalkylcarbonyl radical the heterocycloalkyl radical of which is connected by a carbon atom, alkylcarbonyl, arylcarbonyl or aralkylcarbonyl radical, R2 is H and Y is (CH2)p with p=0, then X is CO-N(R45)-CR46R47)- CO with R45 and R46 being H and R47 is H alkyl, aryl, or aralkyl radical the alkyl and aryl groups of which are optionally substituted. Methods for preparing these compounds, pharmaceutical preparations containing them and their therapeutic use, in particular as calpain inhibitors and/or as trapping agents for reactive oxygen species, whether selectively or not is also disclosed.