Superior solvate form of flavopiridol (Form II) in ethanol as a protein kinase and cyclin dependent kinase inhibitor useful for treating cancer

摘要

An ethanol solvate form of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 [4R-(3S-hydroxy-1-methyl) piperidinyl]-4H-1-benzopyran-4-one (Form II), a method of making Form II and a composition comprising it are described. Also described is the use of the composition in the treatment of cancer.