Reduction of chemical degradation by peroxides and other leachables comprising a pressurised aerosol solution canister with a rubber rim that has rounded edges

摘要

Described is a medicinal aerosol solution formulation product with improved chemical stability of the medicinal aerosol solution, comprising a pressurized metered dose inhaler (10), comprising an aerosol canister (16) equipped with a metering valve (18) and containing a medicinal aerosol solution formulation (12) containing an active ingredient subject to a degradation by means of peroxides or other leachables, a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component, wherein optionally part or all of the internal surfaces of the inhaler consist of stainless steel, anodized aluminium or are lined with an inert organic coating, and wherein the canister has a rim with rounded edges which avoids contact of a sharp edge with the rubbers used as valve gaskets.