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Water-insoluble drugs co-ground with a cross-linked polymeric carrier in dry conditions so they are more soluble and bioavailable
Water-insoluble drugs co-ground with a cross-linked polymeric carrier in dry conditions so they are more soluble and bioavailable
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机译:在干燥条件下,水不溶性药物与交联的聚合物载体共同研磨,因此它们更易溶且可生物利用
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摘要
Described is a process for preparing a highly activated composite of one or more water-insoluble drugs, the process comprising the steps of: (a) subjecting a water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step (a) to contact with water or water vapours. The resulting composite contains large amounts of drug in the easily soluble amorphous form, reduced amounts of drug in the nanocrystalline form, and is substantially free from insoluble drug crystals.
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